Mevalonate Ageing
There are 3 main driving factors of ageing:
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direct cell death by radiation (UV, radioactivity, heat) and ROS (prolonged cell stress)
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cell senescence and death by shortened telomeres (programmed cell death)
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reduced function of cell pathways like the glucose or mevalonate pathways
Point one is best counteracted with antioxidants, which reduce ROS and the damage by them. And of course by avoiding the negative influences like UV, smoke, inflammation in the first place.
Point two is determined by genes in all humans equally and limits the count of cell divisions over the lifetime. Best way to deal with this is not wasting cell generations by point one influences (particularly in younger years, when it’s still not visible).
Point three is when the complex net of signals within the body is gets out of balance. One example is the glucose pathway in insulin resistance, leading to glycation of proteins and more.
And the Mevalonate pathway, which governs many life functions like energy production, repair and growth.
The Mevalonate-Pathway
...is the pathway which begins by making mevalonate from food. And from this many of the essential life molecules in humans, animals and plants. These include coenzyme Q10, cholesterol, all carotenes, some vitamins, immunoglobulins, hormones, muscles and much more.
The mevalonate pathway appears to decline with increasing age and is directly linked to many signs of ageing. For example, with coenzyme Q10, muscle mass and sex hormones.
A good example is Coenzyme Q10 (also known as ubiquinol or CoQ10 for short). There are studies that investigated the reduction of CoQ10 with age [1]. THe data is shown in the title picture.
As we can see, CoQ10 in the heart decreases by 30% at the age of 40 and by 57% at the age of 80. This explains the decline in performance over the years, as CoQ10 is necessary for the production of ATP energy in the mitochondria.
There are similar graphs for declining muscle mass and sex hormones with age. These are all end products of the mevalonate pathway.
Is there nothing we can do, are we doomed to these phenomena?
... proceed reading the PDF here ...
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